Fan-made Pathogenic community wiki

Pathogenic

Verified guides for smarter pathogen builds, organelle synergies, traits, seeded runs, and the route through the human body.

Released Jul 16 20267 Playable Pathogens6 Main Organs120+ Organelles & Mutations
⌕
Start here

Your Pathogenic Journey

All guides →
Build around a core

Best Build Cores

Use one coherent engine, then spend layout space on pieces that actually reinforce it.

All builds →
Explore organelles

Mechanics before rankings.

The organelle database separates official mechanics from editorial advice, so patch-sensitive values never masquerade as permanent facts.

Browse organelle database →
Evidence standard

Verified ≠ guessed

✓

Official mechanic
Developer patch notes or official game material.

△

Patch-sensitive
Exact values can change and are labeled accordingly.

?

Unverified live tooltip
No invented numbers just to fill a page.

Path through the body

Six Organ Route

A route view rather than a generic card wall.

Open walkthrough →
01SkinEntry→
02IntestinesMaze + villi→
03StomachTight-space AOE→
04LiverUpdated room pool→
05LungsAbrupt airflow→
06HeartFinal-area patch notes
Mechanics & systems

Use the tools the game actually gives you.

Evolution preview, cancellable organelle pickups, seeded dailies, plasmid trees, and difficulty settings all change how you plan a run.

Pathogenic Wiki FAQ

Fast answers

What is Pathogenic?

A 2D roguelike twin-stick shooter where you play as a parasite, collect organelles, and evolve through the human body.

How many playable pathogens are there?

The 1.0 launch announcement states there are 7 distinct playable pathogens.

How many organ areas are in the main progression?

The full release announcement describes 6 vibrant organs, with a secret level also hinted.

Why are some organelles marked unranked?

If current public sources do not verify the live tooltip, this site leaves the item unranked instead of inventing data.